Abhay Chakra Sadineni

Work

Ventures, systems, frameworks and analysis

Operating roles where the judgment is applied, and the instruments built so it can be applied again.

Hosted work

Tools, dashboards and visualizations

Biophysics - Structure and temperature in, energy and light out

The Molecular Digital Twin

A digital twin of one biomolecule. Travel from the cuvette down to the electron orbitals of a single protein; change temperature, pH and sequence and watch the shapes, the stability and the spectrum move; run a simulated instrument and see the twin correct itself. Real protein structures from the Protein Data Bank and measured fluorescent-protein spectra from FPbase; the stability and the instrument are synthetic and labelled as such.

Digital twinsBiophysicsSpectroscopy
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Industrial organization · where an industry keeps its memory

The Pedicle

Cut a branch of a growing antler, shed the whole antler, and the next one grows the cut. The memory cannot live in the antler. The same question for an industry after a recession: three candidate stores grown side by side on one site, wounded and cast; the US casts of 2008 and 2020 measured on 2,900 metro-industry cells from BLS QCEW; and a hashed forecast for 2026, written before the data exist, that the page will score against itself.

Industrial organizationApplied AIForecasting
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Applied AI · A control plane over a scientific instrument

The Photon Scheduler

Decide what to measure next. An agent runs a fluorescence instrument on a simulated cell: it turns an intent into lasers, filter bands, exposures and lifetime gates, re-plans as the dyes bleach, stops when it knows enough, and is compared with the fixed protocol at equal light dose. At the hours scale it learns which cells to watch. Real spectra and lifetimes from FPbase; the physics and every assumption written out.

Applied AIBiophotonicsProduct strategy
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Life sciences @ past, present and future

The Healthcare Counterfactual

Which molecule decides which company's fate. Every line Medicare paid for from 2020 to 2024, who makes it and how much of their book it carries, when it is expected to lose exclusivity, what Medicare has negotiated, what is in the active pipeline by area and modality, what the device makers, payers and providers file each quarter, and a deal simulator that buys real facilities and draws the no-deal path beside the deal. Public record only, refreshed daily.

HealthcareLife sciencesValuation
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Counterfactual Valuation

The AI Counterfactual

What did AI add to a business, against the same business without it? Twelve worked cases with causal estimates, P&L bridges, source-to-dollar lineage, alternative worlds, welfare kept separate from profit, and adversarial tests. Runs entirely in the browser.

Economic consultingAIValuation
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